Publications and Patents
49. Bankar, O. S.; Laha, D.; Meher, K. B.; Bhat, R. G. Umpolung Reactivity of Diazo Arylidene Succinimides: Distal C−H Functionalization of α-Thiocarbonyls from the Reactive Carbenoid Center. Chem Asian J. 2023, e202300774.
48. Bhowmick, A.; Chatterjee, A.; Pathak, S. S.; Bhat, R. G. A Visible Light-driven Direct Synthesis of Industrially Relevant Glutaric Acid Diesters from Aldehydes. Chem. Commun. 2023, DOI:10.1039/d3cc02557h.
47. Shaikh, J. Y.; Bhowmick, A.; Chatterjee, A.; Thombare, N. A.; Bhat, R. G. Transient Directing Group Enabled C3-(sp2)-H Alkenylation of Five Membered Heterocyclic Aldehydes: An Access to Mechanochromic Luminogen. Adv. Synth. Catal. 2023, DOI:10.1002/adsc.202300528.
46. Khade, V. V.; Bhowmick, A.; Thube, A. S.; Bhat, R. G. Direct Access to Strained Fused Dihalo-Aziridino Quinoxalinones via C3-Alkylation Followed by Tandem Cyclization. J. Org. Chem. 2023, 88, 8010−8023.
45. Sabale, A. S.; Warghude, P. K.; Bhat, R. G. An Efficient Route to Access Spirooxindole Pyrazolone Fused Cyclopentene via Diastereoselective [3+2] Annulation. Synlett 2023 DOI: 10.1055/a-2014-2813.
44. Dharpure, P. D.; Behera, M.; Thube, A. S.; Bhat, R. G. Base Dependent Rearrangement of Dithiane and Dithiolane under Visible-light Photoredox catalysis. Chem Asian J. 2023, 18, e2022011.
43. Dharpure, P. D.; Behera, M.; Khade, V. V.; Thube, A. S.; Bhat, R. G. A Direct Access to Thiocyano-Thioesters from Cyclic Thioacetals via Photoredox Catalysis: An Introduction of Two Functional groups in One-Pot. Org. Lett. 2022, 24, 6919–6924.
42. Bhowmick, A.; Warghude, P. K.; Bhat, R. G. Visible Light Promoted Metal-Free Sustainable Reduction of α-Alkylidene Oxindoles/Succinimides. Asian J. Org. Chem. 2022, 11, e202200205.
41. Warghude, P. K.; Bhowmick, A.; Bhat, R. G. Direct access to spirooxindole dihydropyrrole fused pyrazolones and bis-spiropyrazolone derivatives. Tetrahedron Lett. 2022, 97, 153791
40. Laha, D.; Meher, K. B.; Bankar, O. S.; Bhat, R. G. Silver-Catalyzed One-Pot Access to Diastereoselective Benzo[5,6]oxepino[2,3-c]pyrroles via Formal (5+2)-Annulation of Donor-/Acceptor-Type Aryl Vinyl Diazosuccinimide with Ketones. Asian J. Org. Chem. 2022,11, e202200062.
39. Khade, V. V.; Thube, A. S.; Dharpure, P. D.; Bhat, R. G. Direct synthesis of 1,3-dithiolanes from terminal alkynes via visible light photoredox catalysis. Org. Biomol. Chem. 2022, 20, 1315-1319.
38. Navale, B. S.; Laha, D.; Banerjee, S.; Vanka, K.; Bhat, R. G. Highly Site-Selective Direct C−H Bond Functionalization of Unactivated Arenes with Propargyl α‑Aryl-α-diazoacetates via Scandium Catalysis. J. Org. Chem. 2022, 87, 13583–13597.
37. Khade, V. V.; Thube, A. S.; Warghude, P. K.; Bhat, R. G. DABCO mediated one pot synthesis of sulfoxonium ylides under blue LED. Tetrahedron Lett. 2021, 77, 153258.
36. Bhowmick, A.; Warghude, P. K.; Dharpure, P. D.; Bhat, R. G. Direct access to α-acyloxycarbonyl compounds and esters via oxidative esterification of aldehydes under visible light. Org. Chem. Front. 2021, 8, 4777.
35. Warghude, P. K.; Sabale, A. S.; Dixit, R.; Vanka, K.; Bhat, R. G. An easy and practical approach to access multifunctional cylcopentadiene- and cyclopentene spirooxindoles via [3 + 2] annulation. Org. Biomol. Chem. 2021,19, 4338.
34. Reddy, C.; Shaikh, J. Y.; Bhat, R. G. Access to Hetero-Benzyl Scaffolds via Transient-Ligand-Enabled Direct γ-C(sp3)–H Arylation of 3-Methylheteroarene-2-Carbaldehydes J. Org. Chem. 2020, 85, 6924–6934.
33. Laha, D.; Bhat, R. G. Silver‐Catalyzed Epoxidation of Aldehydes Using Donor‐/ Acceptor‐type Vinyl Diazosuccinimides to Access Spiro‐Pyrrolidinedioneoxiranes Asian J. Org. Chem. 2020, 9, 918-921. #Top Cited Article 2020-2021.
32. Warghude, P. K.; Sabale, A. S.; Bhat, R. G. Access to highly enantioselective and diastereoselective spirooxindole dihydrofuran fused pyrazolones Org. Biomol. Chem. 2020, 18, 1794-1799.
31. Dharpure, P. D.; Bhowmick, A.; Warghude, P. K.; Bhat, R. G. Visible-light mediated facile dithiane deprotection under metal free conditions Tetrahedron Lett. 2020, 61, 151407.
30. Navale, B. S.; Laha, D. and Bhat, R.G. Propargyl α-aryl-α-diazoacetates as robust reagents for the effective C–H bond functionalization of 1,3-diketones via scandium catalysis Tetrahedron Lett. 2019, 60, 1899–1903.
29. Khopade, T.M.; Warghude, P.K.; Sonawane, A.D. and Bhat, R. G. Multicomponent synthesis of pyroglutamic acid derivatives via Knoevenagel–Michael-hydrolysis-lactamization-decarboxylation (KMHL-D) sequence Org. Biomol. Chem. 2019, 17, 561–566
28. Khopade, T.M.; Warghude, P.K.; Mete, T.B. and Bhat, R. G. Acyl/aroyl Meldrum’s acid as an enol surrogate for the direct organocatalytic synthesis of α,β-unsaturated ketones Tetrahedron Lett. 2019, 60, 197-200
27. L V.R. Babu syamala, Khopade, T.M.; Warghude, P.K. and Bhat, R. G. An access to α, β-unsaturated ketones via dual cooperative catalysis Tetrahedron Lett. 2019, 60, 88-91
26. Warghude,P.K.; Dharpure,P.D.and Bhat, R. G. Cycloaddition of isatin-derived MBH carbonates and 3-methyleneoxindoles to construct diastereoselective cyclopentenyl bis-spirooxindoles and cyclopropyl spirooxindoles: Catalyst controlled [3 + 2] and [2 + 1] annulations Tetrahedron Lett. 2018, 59,4076-4079
25. L.V.R. Babu Syamala.; Mete,T, B. and Bhat, R. G. FeCl3·6H2O-catalyzed selective conjugate reduction of alkylidene-β-keto esters and alkylidene-1,3-diketones Tetrahedron Lett. 2018, 59, 3288–3291
24. Mete,T, B.; Debasish, Laha and Bhat, R. G. A One Pot Transition‐Metal‐Free Synthesis of Styrenyl Ethers from 2‐Aryloxy/Alkoxy Acetophenones ChemistrySelect 2018, 3, 7656 – 7659
23. Khopade, T, M,; Mete,T, B.; Arora, S, J. and Bhat, R. G. An Adverse Effect of Higher Catalyst Loading and Longer Reaction Time on Enantioselectivity in an Organocatalytic Multicomponent Reaction Chem. Eur.J. 2018, 24, 6036 –6040
22. L.V.R. Babu Syamala and Bhat, R. G. FeCl3·6H2O catalyzed diastereoselective synthesis of (L)-menthyl 4-oxo-2-arylpiperidine-3-carboxylates Tetrahedron Lett. 2017, 58, 4836-4840.
21. Mete, T, B.; Singh, A. and Bhat, R. G. Transition-metal-free synthesis of primary to tertiary carboxamides: A quick access to prodrug-pyrazinecarboxamide Tetrahedron Lett. 2017, 58, 4709-4712.
20. Khopade, T, M,; Sonawane, A, D.; Arora, S, J. and Bhat, R. G. Direct Organocatalytic Multicomponent Synthesis of Enantiopure γ‐Butyrolactones via Tandem Knoevenagel‐Michael‐Lactonization Sequence Adv. Synth. Catal. 2017,359, 3905–3910
19. Mete, T, B.; Khopade, T, M and Bhat, R. G. Oxidative decarboxylation of arylacetic acids in water: One-pot transition-metal-free synthesis of aldehydes and ketones Tetrahedron Lett. 2017, 58, 2822-2825.
18. Mohite, A.R.; Mete, T, B. and Bhat, R. G. An expedient stereoselective synthesis of (E)-α,β-unsaturated esters and thioesters using FeCl3·6H2O Tetrahedron Lett. 2017, 58, 740-774.
17. Mete, T, B.; Khopade, T, M and Bhat, R. G. Transition-metal-free regioselective thiocyanation of phenols, anilines and heterocycles Tetrahedron Lett. 2017, 58, 415-418 .
16. Sultane, P. R.; Mete, T. B.; Bhat, R. G. Chemoselective N- deacetylation under mild conditions Org. Biomol. Chem. 2014, 12, 261-264.
15. Mohite, A. R.; Bhat, R. G. A Practical and Convenient Protocol for the Synthesis of (E) - α, β- Unsaturated Acids Org. Lett. 2013, 15, 4564-4567. * (highlighted in Organic Chemistry Portal)
14. Navale, B. S. and Bhat, R. G. Copper (I) Iodide-DMAP catalyzed Homo- and Heterocoupling of Terminal Alkynes RSC Advances 2013, 3, 5220-5226.
13. Sultane, P. R. and Bhat R. G. Stereoselective Approach to cis-2,3 Disubstituted Piperidines via Reduction of N-acyliminium ion intermediate: Enantioselective Synthesis of (+)-(2S,3S)-CP-99,994 J. Org. Chem. 2012, 77, 11349–11354 * (highlighted in Organic Chemistry Portal)
12. Sultane, P. R., Mohite, A. R. and Bhat, R. G. Total synthesis of 1-deoxy-7,8a-di-epi-castanospermine and formal synthesis of pumiliotoxin-251D Tetrahedron Lett. 2012, 53, 5856-5858.
11. Mohite, A. R and Bhat, R. G. Enantiopure Synthesis of Side Chain-Modified α-Amino Acids and 5-cis-Alkylprolines J. Org. Chem. 2012, 77, 5423-5428.
10. Mohite, A. R., Sultane, P. R., and Bhat, R. G. BF3.Et2O and Trifluoroacetic acid/Triethylamine mediated synthesis of Functionalized Piperidines. Tetrahedron Lett. 2012, 53, 30-35. * (Highlighted in ChemInform, 2012, 43, Issue 17)
Ph.D and Post-Doctoral publications
9. Bhat, R. G.; Kumar, N. S.; Pinto, B. M. Synthesis of phosphate derivatives related to the glycosidase inhibitor salacinol Carbohydrate
Research, 2007, 342, 1934-1942
8. Choubdar N.; Bhat, R. G.; Stubbs, Keith A.;Scott Y.; Pinto B.M. Synthesis of 2-amido, 2-amino, and 2-azido derivatives of the
nitrogen analogue of the naturally occurring glycosidase inhibitor salacinol and their inhibitory activities against O-GlcNAcase
and NagZ enzymes Carbohydrate Research, 2008, 343, 1766-1777
7. Synthesis and applications of proprgyl pentafluorophenyl carbonate for peptide synthesis. Bhat, R. G.; Kerouredan, E.; Porhiel,
E.; Chandrasekaran, S. Tetrahedron Lett. 2002, 43, 2467-2469.
6. Propargyloxycarbonyl (Poc) amino acid chlorides as efficient coupling reagents for the synthesis of 100% diastereopure
Peptides and resin bound tetrathiomolybdate as an effective deblocking agent for the Poc group. Bhat, R. G.; Sinha, S.;
Chandrasekaran, S. Chem. Commun. 2002, 812-813.
5. Utility of tetrathiomolybdate and tetraselenotungstate: efficient synthesis of cystine, selenocystine, and their higher homologues.
Bhat, R. G.; Porhiel. E.; Saravanan, V. Tetrahedron Lett. 2003, 44, 5251-5253.
4. Bhat, R. G.; Ghosh, Y.; Chandrasekaran, S. A mild and selective method for N-dealkylation of tertiary amines Tetrahedron Lett.
2004, 45, 7983-7985. (Cited in Current Opinion in Drug Discovery & Development 2005, 8, 10. as an outstanding significance)
3. Ramesh, R.; Bhat, R. G.; Chandrasekaran, S. Highly Selective Deblocking of Propargyl Carbonates in the Presence of Propargyl
Carbamates with Tetrathiomolybdate J. Org. Chem. 2005, 70, 837-840.
2. Dots, dashes, and Hydrogen bonds. Bhat, R. G. and Gudihal, R. Current Science, 2003, 85, 839.
1. C-H···F interaction overshadows favorable C-H···O interaction in propargyl pentafluorophenyl carbonate (PocOPfp). Roy, A.;
Bhat, R. G.; Row, G.; Chandrasekaran, S. Crystal Growth & Design, 2007, 7, 844-846
Patents
1. Bhat, R. G., and Mohite, A. R. Synthesis of α, β--Unsaturated Carboxylic Acids and Esters Provisional Patent filed in India, App No.: 2437/MUM/2013.
2. Pinto, Brian M.; Kumar, Nag Sharwan; Bhat, Ramakrishna G.; Liu, Hui; Nasi, Ravindranath; Chen, Wang; Mohan, Sankar. Preparation of salacinol analogs alditols as glycosidase inhibitors. U.S. Pat. 2007, 35 pp. US 2007244184 A1 20071018